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Title: Genetic ancestry and income are associated with dengue Genetic ancestry and income are associated with dengue hemorrhagic fever in a highly admixed population
Other Titles: European Journal of Human Genetics
Authors: Blanton, Ronald Edward
Silva, Luciano K.
Morato, Vanessa G.
Parrado, Antonio R.
Dias, Juarez Pereira
Melo, Paulo Roberto Santana de
Reis, Eliana A. G.
Goddard, Katrina A. B.
Nunes, Márcio Roberto Teixeira
Rodrigues, Sueli G.
Vasconcelos, Pedro F. C.
Castro, Jesuina M.
Reis, Mitermayer Galvão dos
Barreto, Mauricio Lima
Teixeira, Maria da Glória Lima Cruz
Keywords: ethnicity;race;population structure;socioeconomic status;DENV3
Issue Date: 13-Feb-2008
Abstract: To test whether African ancestry is protective for severe dengue, we genotyped 49 hospitalized cases of dengue hemorrhagic fever(DHF)as well as 293 neighborhood cases of dengue fevre and 294 asymptomatic controls in Salvador, Bahia, Brazil.Ancestry-informative markers and 282 unlinked SNPs not associated with the clinical presentation of dengue were used to estimate ancestry. After controlling for income,both self-defined Afro-Brazilian ethnicity and African ancestry were protective for DHF (P=0.02, OR=0.28 and P=0.02,OR=0.13,respectively).Income or an index of income indicators, however,was also independently associated with the diagnosis of DHF.
Description: p.762-765
URI: http://www.repositorio.ufba.br/ri/handle/ri/2060
ISSN: 1018-4813/08
Appears in Collections:Artigos Publicados em Periódicos Estrangeiros (ISC)

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