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|Title: ||A genome-wide association study of asthma symptoms in Latin American children|
|Other Titles: ||BMC Genet|
|Authors: ||Costa, Gustavo N. O.|
Fiaccone, Rosemeire Leovigildo
Silva, Thiago M. da
Figueiredo, Camila A.
Rodrigues, Laura C.
Barreto, Mauricio Lima
|Keywords: ||Asthma symptoms;Genome-wide association;Latin America;Children|
|Issue Date: ||Dec-2015|
|Publisher: ||BioMed Central|
|Abstract: ||Background: Asthma is a chronic disease of the airways and, despite the advances in the knowledge of associated genetic regions
in recent years, their mechanisms have yet to be explored. Several genome-wide association studies have been carried out in recent years, but none of these have involved Latin American populations with a high level of miscegenation, as is seen in the Brazilian population. Methods: 1246 children were recruited from a longitudinal cohort study in Salvador, Brazil. Asthma symptoms were identified in accordance with an International Study of Asthma and Allergies in Childhood (ISAAC)questionnaire.
Following quality control, 1 877 526 autosomal SNPs were tested for association with childhood asthma symptoms by logistic regression using an additive genetic model. We complemented the analysis with an stimate of the phenotypic variance explained by common genetic variants. Replications were investigated in independent Mexican and US Latino samples. Results: Two chromosomal regions reached genome-wide significance level for childhood asthma symptoms: the
14q11 region flanking the DAD1 and OXA1L
genes (rs1999071, MAF 0.32, OR 1.78, 95 % CI 1.45–2.18, p-value 2.83 × 10−8)and 15q22 region flanking the FOXB1 gene (rs10519031, MAF 0.04, OR 3.0, 95 % CI 2.02–4.49,p-value 6.68 × 10−8 and rs8029377, MAF 0.03, OR 2.49, 95 % CI 1.76–3.53, p-value 2.45 × 10−
7). eQTL analysis suggests that rs1999071 regulates the expression of OXA1L gene. However, the original findings were not replicated in the Mexican or US Latino samples. Conclusions: We conclude that the 14q11 and 15q22 regions may be associated with asthma symptoms in childhood.|
|Appears in Collections:||Artigos Publicados em Periódicos Estrangeiros (ISC)|
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