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Please use this identifier to cite or link to this item: http://repositorio.ufba.br/ri/handle/ri/19061

Title: A genome-wide association study of asthma symptoms in Latin American children
Other Titles: BMC Genet
Authors: Costa, Gustavo N. O.
Dudbridge, Frank
Fiaccone, Rosemeire Leovigildo
Silva, Thiago M. da
Strina, Agostino
Figueiredo, Camila A.
Rodrigues, Laura C.
Barreto, Mauricio Lima
Keywords: Asthma symptoms;Genome-wide association;Latin America;Children
Issue Date: Dec-2015
Publisher: BioMed Central
Abstract: Background: Asthma is a chronic disease of the airways and, despite the advances in the knowledge of associated genetic regions in recent years, their mechanisms have yet to be explored. Several genome-wide association studies have been carried out in recent years, but none of these have involved Latin American populations with a high level of miscegenation, as is seen in the Brazilian population. Methods: 1246 children were recruited from a longitudinal cohort study in Salvador, Brazil. Asthma symptoms were identified in accordance with an International Study of Asthma and Allergies in Childhood (ISAAC)questionnaire. Following quality control, 1 877 526 autosomal SNPs were tested for association with childhood asthma symptoms by logistic regression using an additive genetic model. We complemented the analysis with an stimate of the phenotypic variance explained by common genetic variants. Replications were investigated in independent Mexican and US Latino samples. Results: Two chromosomal regions reached genome-wide significance level for childhood asthma symptoms: the 14q11 region flanking the DAD1 and OXA1L genes (rs1999071, MAF 0.32, OR 1.78, 95 % CI 1.45–2.18, p-value 2.83 × 10−8)and 15q22 region flanking the FOXB1 gene (rs10519031, MAF 0.04, OR 3.0, 95 % CI 2.02–4.49,p-value 6.68 × 10−8 and rs8029377, MAF 0.03, OR 2.49, 95 % CI 1.76–3.53, p-value 2.45 × 10− 7). eQTL analysis suggests that rs1999071 regulates the expression of OXA1L gene. However, the original findings were not replicated in the Mexican or US Latino samples. Conclusions: We conclude that the 14q11 and 15q22 regions may be associated with asthma symptoms in childhood.
URI: http://repositorio.ufba.br/ri/handle/ri/19061
ISSN: 1471-2156
Appears in Collections:Artigos Publicados em Periódicos Estrangeiros (ISC)

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