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Please use this identifier to cite or link to this item: http://repositorio.ufba.br/ri/handle/ri/17845

Title: Impaired T Helper 2 Response to Aeroallergen in Helminth-Infected Patients with Asthma
Other Titles: Journal of Infectious Diseases
Authors: Araujo, Maria Ilma Andrade Santos
Hoppe, Bradford
Medeiros Junior, Manoel
Alcântara, Leda Maria
Almeida, Maria Cecilia Freitas de
Schriefer, Nicolaus Albert Borges
Oliveira, Ricardo Riccio
Kruschewsky, Ramon de Almeida
Figueiredo, Joanemile Pacheco de
Cruz Filho, Álvaro Augusto Souza da
Carvalho Filho, Edgar Marcelino de
Keywords: Asthma;Interleukin-4;Interleukin-5;Asma;Interleucina-4;Th2 Cells;Interleucina-5;Células TH2
Issue Date: 2004
Abstract: Helminthic infections have been shown to inhibit allergy skin-prick tests and to modify the course of asthma. We evaluated Dermatophagoides pteronyssinus-specific immune responses in patients with asthma by measuring levels of T helper 2 (Th2) cytokines in peripheral blood mononuclear cell (PBMC) cultures. PBMCs from Schistosoma mansoni-infected patients with asthma living in an area of polyhelminthic endemicity produced lower levels of interleukin (IL)-5 and IL-4 in response to D. pteronyssinus antigen (Ag) 1 than did PBMCs from helminth-free patients with asthma. In contrast, D. pteronyssinus Ag 1-specific production of IL-10 was higher in helminth-infected patients than in helminth-free patients. The addition of recombinant human IL-10 to D. pteronyssinus Ag 1-stimulated cultures of PBMCs from helminth-free patients led to downmodulation of production of IL-5. After helminth-infected patients with asthma received antihelminthic treatment, there was down-modulation of D. pteronyssinus Ag 1-specific production of IL-10 in vitro. S. mansoni-infected patients with asthma produce lower levels of Th2 cytokines than do helminth-free patients with asthma, and this modulation is likely done by IL-10.
Description: Texto completo: acesso restrito. p. 1797-1803
URI: http://repositorio.ufba.br/ri/handle/ri/17845
ISSN: 0022-1899
Appears in Collections:Artigos Publicados em Periódicos (Medicina)

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