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Please use this identifier to cite or link to this item: http://repositorio.ufba.br/ri/handle/ri/17666

Title: Identification of novel recombinants of hepatitis B virus genotypes F and G in human immunodeficiency virus-positive patients from Argentina and Brazil
Other Titles: Journal of General Virology
Authors: Araujo, Natália Motta de
Araujo, Oscar Rafael Carmo
Silva, Edinete Melo da
Villella-Nogueira, Cristiane Alves
Nabuco, Letícia Cancella
Paraná, Raymundo
Bessone, Fernando
Gomes, Selma de Andrade
Trepo, Christian
Kay, Alan Campbell
Keywords: Hepatitis B;Hepatitis B virus;HBeAg;AIDS Serodiagnosis
Issue Date: 2013
Abstract: Hepatitis B virus (HBV) genotype G (HBV/G) infection is almost always detected along with a co-infecting HBV strain that can supply HBeAg, typically HBV/A2. In this study we describe, in two human immunodeficiency virus (HIV)-positive patients from Argentina and Brazil, the first report of HBV/G infection in Argentina and co-circulation of HBV/G, HBV/F and G/F recombinants in the American continent. HBV isolates carrying the 36 bp insertion of HBV/G were the most prevalent in both patients, with >99 % of colonies hybridizing to a probe specific for this insertion. Phylogenetic analyses of full-length genomes and precore/core fragments revealed that F4 and F1b were the co-infecting subgenotypes in the Brazilian and Argentinian patients, respectively. Bootscanning analysis provided evidence of recombination in several clones from both patients, with recombination breakpoints located mainly at the precore/core region. These data should encourage further investigations on the clinical implications of HBV/G recombinants in HBV/HIV co-infected patients.
Description: Texto completo: acesso restrito. p.150-158
URI: http://repositorio.ufba.br/ri/handle/ri/17666
ISSN: 0022-1317
Appears in Collections:Artigos Publicados em Periódicos (Medicina)

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