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Please use this identifier to cite or link to this item: http://repositorio.ufba.br/ri/handle/ri/16860

Title: Porphyromonas gingivalis HmuY-Induced Production of Interleukin-6 and IL-6 Polymorphism in Chronic Periodontitis
Other Titles: Journal of Periodontology
Authors: Trindade, Soraya Castro
Olczak, Teresa
Gomes Filho, Isaac Suzart
Costa, Lília Ferreira de Moura
Vale, Vera Costa
Galdino Neto, Milton
Santos, Heidiane Alves dos
Carvalho Filho, Paulo Cirino de
Stöcker, Andreas
Bendicho, Maria Teresita Del Niño Jesus Fernandez
Xavier, Márcia Tosta
Cerqueira, Eneida de Moraes Marcílio
Nascimento, Roberto José Meyer
Keywords: Interleukin-6;Periodontitis;Porphyromonas gingivalis
Issue Date: 2013
Abstract: Background: In chronic periodontitis (CP), the gene polymorphism of interleukin-6 (IL-6) to 174C/G has been associated with the altered production of this cytokine. The aim of this pilot study is to compare the allelic and genotypic frequencies in patients with CP with control individuals without periodontitis (NP) and to measure the production of IL-6 by whole blood cells stimulated with Porphyromonas gingivalis HmuY protein. Methods: DNA was isolated from peripheral blood cells of 49 patients with CP and 60 control individuals classified as NP, and genotyping was performed by polymerase chain reaction using sequence-specific primers. Whole blood cells from 29 patients with CP and 30 control individuals were stimulated for 48 hours with HmuY, and IL-6 levels were measured using enzyme-linked immunosorbent assay. Results: The proportion of individuals carrying the G allele at position –174 of the IL-6 gene was higher in the group with CP (85.7%) than in the normal control group (73.3%; P <0.03). P. gingivalis HmuY-induced production of IL-6 was higher in the group with CP (P <0.05). Conclusions: Our findings suggest that P. gingivalis HmuY may be associated with increased IL-6 production during CP. Furthermore, patients with periodontitis and individuals with higher HmuY-induced production of IL-6 show a high frequency of the G allele at position –174.
Description: Acesso restrito: p. 650-655
URI: http://repositorio.ufba.br/ri/handle/ri/16860
ISSN: 0022-3492
Appears in Collections:Artigos Publicados em Periódicos (Medicina)

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