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Please use this identifier to cite or link to this item: http://repositorio.ufba.br/ri/handle/ri/16672

Title: American Cutaneous Leishmaniasis unresponsive to antimonial drugs: successful treatment using combination of N-Methilglucamine Antimoniate plus Pentoxifylline
Other Titles: International Journal of Dermatology
Authors: Báfica, Andre Luiz Barbosa
Oliveira, Luiz Fabiano Borges
Freitas, Luiz Antonio Rodrigues de
Nascimento, Eliane G.
Barral, Aldina Maria Prado
Keywords: Leishmaniasis, Cutaneous;Ulcer;Pentoxifylline
Issue Date: 2003
Abstract: Background American cutaneous leishmaniasis is characterized by single or multiple ulcerations. Cytokines, among other factors, have been shown to influence lesion development and tumoral necrosis factor-alpha is a major cytokine implicated in pathogenesis of ulcers. Observations We tested oral pentoxifylline, a known tumoral necrosis factor-alpha inhibitor, at doses of 400 mg (2–3x/day), associated to N-methylglucamine antimoniate (15 mg/kg/day) in two patients with American cutaneous leishmaniasis unresponsive to antimonial drugs. We observed a satisfactory response with quick cure of skin lesions of these patients. Conclusions Our results suggest that oral pentoxifylline in association to N-methylglucamine antimoniate should be consider in refractory cutaneous leishmaniasis patients.
Description: Texto completo: acesso restrito. p. 203–207
URI: http://repositorio.ufba.br/ri/handle/ri/16672
ISSN: 0011-9059
Appears in Collections:Artigos Publicados em Periódicos (Medicina)

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