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Please use this identifier to cite or link to this item: http://repositorio.ufba.br/ri/handle/ri/16641

Title: Failure of early treatment of Cutaneous Leishmaniasis in preventing the development of an ulcer
Other Titles: Clinical Infectious Diseases
Authors: Machado, Paulo Roberto Lima
Araújo, Cibele
Silva, Andréa T. da
Almeida, Roque Pacheco de
D'Oliveira Junior, Argemiro
Bittencourt, Achilea Candida Lisboa
Carvalho Filho, Edgar Marcelino de
Keywords: Leishmaniasis, Cutaneous;Ulcer
Issue Date: 2002
Abstract: The clinical characteristics and treatment outcome were determined for 26 patients who presented with early-stage cutaneous leishmaniasis. Illness duration ranged from 8 to 20 days, and the commonest clinical presentation was the presence of a papule with small central crust on a lower extremity. Prominent regional adenopathy was found in 22 (85%) of 26 patients. The results of an intradermal skin test for Leishmania were positive for 96% of those patients, and results of serologic testing were positive for 61% of patients tested. Ten (46%) of 22 patients for whom follow-up data were available developed enlargement and ulceration of the lesion despite early antimony therapy and required additional courses of treatment. Histopathological studies of samples from the lesions of 3 patients showed vasculitis. These data show that early therapy for cutaneous leishmaniasis does not prevent the development of an ulcer in one-half of patients. This unfavorable outcome underlines the relevance of local exacerbated inflammatory and immune response in the pathogenesis of the disease.
Description: Texto completo: acesso restrito. p. 69-73
URI: http://repositorio.ufba.br/ri/handle/ri/16641
ISSN: 1058-4838
Appears in Collections:Artigos Publicados em Periódicos (Medicina)

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