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Please use this identifier to cite or link to this item: http://repositorio.ufba.br/ri/handle/ri/16369

Title: Distribution of mast cells in benign odontogenic tumors
Other Titles: Tumor Biology
Authors: Pereira, Francisco de Assis Caldas
Gurgel, larissa Araújo Silva
Ramos, Eduardo Antônio Gonçalves
Vidal, Manuela Torres Andion
Pinheiro, Antonio Luiz Barbosa
Jurisic, Vladimir
Sales, Caroline Brandi Schlaepfer
Cury, Patricia Ramos
Santos, Jean Nunes dos
Keywords: Mast cell;Immunohistochemistry;Odontogenic tumors;Ameloblastomas
Issue Date: 2012
Abstract: The aim of this study was to investigate the presence of mast cells in a series of odontogenic tumors. Forty-five cases of odontogenic tumors were investigated using immunohistochemistry for mast cell triptase, and differences between groups were statistically evaluated. Mast cells were present in 96% of odontogenic tumors. Mast cells present in solid ameloblastoma were observed in the tumor stroma surrounding more solid and follicular epithelial islands, with or without squamous metaplasia. The odontogenic mixoma showed few mast cells. In odontogenic tumors with a cystic structure, the mast cells were distributed throughout all areas of the lesions, mainly in keratocystic odontogenic tumor. In addition, the total density of mast cells between all odontogenic tumors showed no significant difference (p > 0.05). A greater mast cells distribution was found in keratocystic odontogenic tumor in relation to adenomatoid odontogenic tumor (p < 0.01), and when the unicystic ameloblastoma and keratocistic odontogenic tumor were compared to the odontogenic myxoma (p < 0.05). Syndrome keratocystic odontogenic tumor showed a higher mean of mast cells when compared with the other tumors of the sample. Mast cells values presented by syndrome keratocystic odontogenic tumor were significantly greater than those of the sporadic keratocystic odontogenic tumor that were not associated with the syndrome (p = 0.03). Mast cells are probably one of the major components of the stromal scaffold in odontogenic tumors. We found significant differences of mast cells between syndrome nonsyndrome keratocystic odontogenic tumors, although their distribution did not seem to have any influence on the biologic behavior of benign odontogenic tumors.
Description: Texto completo: acesso restrito. p. 455-461
URI: http://repositorio.ufba.br/ri/handle/ri/16369
ISSN: 1010-4283
Appears in Collections:Artigos Publicados em Periódicos (Odontologia)

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