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Please use this identifier to cite or link to this item: http://repositorio.ufba.br/ri/handle/ri/16181

Title: Prevalence of non-organ-specific autoantibodies in a rural community from northeastern Brazil: a population-based study
Other Titles: Human Immunology
Authors: Cunha, Liliane Monteiro
Bittencourt, Paulo Lisboa
Lemos, Clarice P. Abrantes
Moreira, Agnaluce
Almeida, Delvone
Paraná, Raymundo
Andrade, Zilton de Araújo
Keywords: Autoantibodies;Rural population;Autoimmunity;Autoimmune diseases;Liver diseases
Issue Date: Jan-2012
Abstract: Non-organ-specific autoantibodies (NOSA) are well-recognized diagnostic markers of autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC), but can also be observed in patients with viral hepatitis as well as in healthy subjects. The aim of this study was to evaluate the prevalence of NOSA in subjects living in a rural community in Brazil and to correlate their occurrence with the presence of liver disease. Seven hundred twenty-five apparently healthy subjects were randomly selected for assessment of antinuclear (ANA), anti-smooth muscle (SMA), antimitochondrial (AMA), anti-liver/kidney microsome type 1, and anti-liver cytosol type 1 antibodies. Subjects with those NOSA were evaluated for the presence of AIH, PBC, and viral hepatitis. Reactivities for all NOSA, SMA, ANA, and AMA were detected, respectively, in 14, 10, 4, and 0.1% of subjects, with a mean titer of 1:40. NOSA-positive subjects were significantly older and more frequently females. No correlation was observed between the occurrence of NOSA and PBC, AIH, or viral hepatitis. The prevalence of NOSA in Brazilians was 14%. They were usually low titer. NOSA were more frequently observed in females and older subjects and their presence was not correlated with the presence of AIH, PBC, or viral hepatitis.
Description: Texto completo: acesso restrito. p. 70–74
URI: http://repositorio.ufba.br/ri/handle/ri/16181
ISSN: 0198-8859
Appears in Collections:Artigos Publicados em Periódicos (Medicina)

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