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Please use this identifier to cite or link to this item: http://repositorio.ufba.br/ri/handle/ri/15964

Title: Urodynamic features of the voiding dysfunction in HTLV-1 infected individuals
Other Titles: International Brazilian Journal of Urology
Authors: Castro, Néviton Matos de
Freitas, Daniel M.
Rodrigues Junior, Waldyr
Muniz, André Luís Nunes
Oliveira, Paulo
Carvalho Filho, Edgar Marcelino de
Keywords: Human T-lymphotropic virus 1;Paraparesis;Tropical spastic;Urinary tract;Urinary bladder;Neurogenic
Issue Date: 2007
Abstract: OBJECTIVE:To describe urodynamic abnormalities in HTLV-1 infected individuals presenting urinary symptoms and verify if these findings and quality of life (QOL) evaluation correlate with overall neurological impairment. MATERIALS AND METHODS: From January/2001 to May/2004, 324 HTLV-1 seropositive subjects were evaluated to determine the occurrence of urinary symptoms. Urodynamic testing was performed in those who complained of frequency, urgency, or incontinence. They went through a complete clinical, neurological, and urological examination to investigate symptoms and signs of myelopathy. Neurological disability was assessed by Expanded Disability Status Scale (EDSS). RESULTS: From the 324 patients evaluated, 78 underwent the urodynamic testing. Fifty-seven individuals were females (73.1%) and age ranged from 23 to 76 years (mean = 48.7 years; SD ± 11.6). Urodynamic testing was abnormal in 63 patients (80.8%). The major abnormality was detrusor overactivity (DO), observed in 33 individuals (33/63; 52.4%), followed by detrusor-external sphincter dyssynergia (DESD), diagnosed in 15 subjects (15/63; 25.4%). HAM/TSP patients had significantly more DESD than the HTLV-I carriers (p = 0.005; OR = 5.5; CI: 1.6 to 19.4). QOL was severely compromised in HAM/TSP patients. CONCLUSIONS: Prominent urodynamic abnormalities were identified in individuals genuinely considered as HTLV-I carriers, suggesting an early compromise of the urinary tract; whereas HAM/TSP patients presented urodynamic findings, which posed a potential risk to the upper urinary tract (dyssynergia). Urodynamic evaluation should be performed in all HTLV-I-infected individuals with voiding complaints.
Description: p. 238-245
URI: http://repositorio.ufba.br/ri/handle/ri/15964
ISSN: 1677-5538
Appears in Collections:Artigos Publicados em Periódicos (Medicina)

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