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Please use this identifier to cite or link to this item: http://repositorio.ufba.br/ri/handle/ri/15217

Title: A new approach to select solvents and operating conditions for supercritical antisolvent precipitation processes by using solubility parameter and group contribution methods
Other Titles: Journal of Supercritical Fluids
Authors: Pereira, V. J.
Matos, R. L.
Cardoso, S. G.
Soares, R. O.
Santana, G. L.
Costa, Glória Meyberg Nunes
Melo, Silvio Alexandre Beisl Vieira de
Keywords: Solvents;Pharmaceuticals;Solubility;Precipitation;Solubilization
Issue Date: 2013
Abstract: A new approach is proposed to select operating temperature and pressure for supercritical antisolvent particle precipitation based on solubility parameter calculated by group contribution methods and using only the critical properties of the solvent. Solubility parameters are also used to choose the most suitable organic solvent for a given application. Supercritical antisolvent precipitation operating conditions of 36 systems are investigated including 8 organic solvents (methanol, ethanol, acetone, DMSO, DCM, chloroform, NMP and acetic acid) and 6 solid solutes (atenolol, tartaric acid, flunisolide, paracetamol, amoxicillin and cholesterol) in the temperature and pressure ranges of 25⿿85 °C and 50⿿250 bar. The results show a good agreement between the experimental and calculated data for these systems. Although particle precipitation depends on several parameters such as mass-transfer rates and hydrodynamics, the focus of this work is on the role of thermodynamics to indicate the preliminary conditions for a successful antisolvent precipitation process. Validation and results of this new approach suggest that it can be a useful tool for a qualitative and completely predictive evaluation of supercritical antisolvent particle precipitation in a cheaper way than carrying out experimental runs.
Description: Texto completo: acesso restrito. p. 128–146
URI: http://repositorio.ufba.br/ri/handle/ri/15217
ISSN: 0896-8446
Appears in Collections:Artigos Publicados em Periódicos (PEI)

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