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Please use this identifier to cite or link to this item: http://repositorio.ufba.br/ri/handle/ri/15167

Title: Evaluation of the Effects of Polarized Light (λ400–200 nm) on the Healing of Third-Degree Burns in Induced Diabetic and Nondiabetic Rats
Other Titles: Photomedicine and Laser Surgery
Authors: Oliveira, Priscila Chagas
Pinheiro, Antonio Luiz Barbosa
Castro, Isabele C. V. de
Reis Junior, João Alves
Noia, Manuela Pimentel
Gurgel, Clarissa
Cangussu, Maria Cristina Teixeira
Ramalho, Luciana Maria Pedreira
Keywords: Diabetes Mellitus Experimental;Phototherapy;Light;Mice
Issue Date: 2011
Abstract: The study evaluated, by light microscopy, the repair process on third-degree burns on diabetic and nondiabetic rats, illuminated or not, with a polarized light (PL) source. Background data: Burns are severe injuries that result in the loss of fluid and destruction of tissue, infection, and shock that may result in death. Diabetes mellitus is a public health problem that, being uncontrolled, causes severe disturbance to the body metabolism, including on wound healing. PL sources have been shown to be effective in improving healing in many situations. Materials and methods: Ninety male Wistar rats were divided into two groups (n=45): nondiabetic and diabetic. In one of the groups, diabetes mellitus was induced by streptozotocin. A third-degree burn, measuring 1.5×1.5 cm2, was created in the dorsum of each animal. Phototherapy (λ400–2000 nm, 10.2 or 20.4 J/cm2) started immediately after burning and was repeated daily until animal death (7, 14, and 21 days). Specimens were taken, processed, and stained with H&E and Sirius red and immunomarked with cytokeratin (CK) AE1/AE3. Descriptive analysis was performed by light microscopy. Results: Animals subjected to phototherapy showed an acceleration of the repair, the dose of 10.2 J/cm2 being the one that caused best results, including higher deposition of collagen, quicker inflammatory reaction, and improved revascularization. Conclusions: Our results suggest that the use of PL (10.2 J/cm2) improves the healing of third-degree burns on both diabetic and nondiabetic animals.
Description: Texto completo: acesso restrito. p. 619–625
URI: http://repositorio.ufba.br/ri/handle/ri/15167
ISSN: 1549-5418
Appears in Collections:Artigos Publicados em Periódicos (Odontologia)

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