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Please use this identifier to cite or link to this item: http://repositorio.ufba.br/ri/handle/ri/14813

Title: Antihelminthic Therapy and Antimony in Cutaneous Leishmaniasis: A Randomized, Double-Blind, Placebo-Controlled Trial in Patients Co-Infected with Helminths and Leishmania braziliensis
Other Titles: American Journal of Tropical Medicine and Hygiene
Authors: Newlove, Tracey
Guimarães, Luiz H.
Morgan, Daniel J.
Alcântara, Leda Maria
Glesby, Marshall J.
Carvalho Filho, Edgar Marcelino de
Machado, Paulo Roberto Lima
Keywords: Helminthiasis;Leishmaniasis, Cutaneous;Infection
Issue Date: 2011
Abstract: Helminth infections influence the clinical response to certain diseases and are associated with delayed healing time of patients with cutaneous leishmaniasis (CL) caused by Leishmania braziliensis. We conducted a randomized, double-blind, placebo-controlled clinical trial to examine the role of early versus deferred treatment of intestinal helminth infection on the clinical course of patients with CL treated with pentavalent antimony. (Clinicaltrials.gov number NCT00469495). A total of 90 patients were enrolled, 51.1% (N = 23) of control patients had persistent lesions at Day 90, compared with 62.2% (N = 28) in the treatment group (difference 11.1%, 95% confidence interval = −9.1–30.0%). There was no statistically significant difference in overall time to cure between groups, although there was a tendency for shorter cure times in the control group. This study shows that early introduction of antihelminthic therapy does not improve clinical outcome in patients co-infected with helminths and L. braziliensis.
Description: Texto completo: acesso restrito. p. 551-555
URI: http://repositorio.ufba.br/ri/handle/ri/14813
ISSN: 0002-9637
Appears in Collections:Artigos Publicados em Periódicos (Medicina)

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