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Please use this identifier to cite or link to this item: http://repositorio.ufba.br/ri/handle/ri/14746

Title: Modulation of T cell responses in HTLV-1 carriers and in patients with myelopathy associated with HTLV-1
Other Titles: Neuroimmunomodulation
Authors: Santos, Silvane Maria Braga
Porto, Maria Aurélia da Fonseca
Muniz, André Luís Nunes
Luna, Tania
Nascimento, Márcia C.
Guerreiro, Jaqueline B.
OliveiraFilho, Jamary
Morgan, Daniel J.
Carvalho Filho, Edgar Marcelino de
Keywords: Antagonists;Cytokines;HTLV-1;Interferon-γ;Myelopathy;T cell responses
Issue Date: 2007
Abstract: Objective: Human T lymphotropic virus-type 1 (HTLV-1) activates the immune system leading to a persistent and exacerbated T-cell response with increased production of IFN-γ and TNF-α. Overproduction of pro-inflammatory cytokines is correlated with the development of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), although some HTLV-1 carriers also show high levels of these cytokines. In this study, the ability of regulatory cytokines and cytokine antagonists to inhibit spontaneous IFN-γ production was investigated. Method: IFN-γ levels were measured by ELISA before and after addition of cytokines or anti-cytokines. Results: Addition of IL-10 significantly reduced spontaneous IFN-γ synthesis in cell cultures from HTLV-1 carriers, while no differences were observed in HAM/TSP patients. There was also a tendency to decreased IFN-γ levels in cell cultures from HTLV-1 carriers with exogenous addition of TGF-β. In paired analysis, neutralization of IL-2 significantly decreased IFN-γ production in HTLV-1 carriers but not in HAM/TSP patients. Neutralization of IL-15 was less effective than neutralization of IL-2 in modulating IFN-γ production. In HTLV-1 carriers, anti-IL-2 and simultaneous addition of anti-IL-2 and anti-IL-15 decreased IFN-γ synthesis by 46 and 64%, respectively, whereas in patients with HAM/TSP simultaneous neutralization of both anti-cytokines only decrease IFN-γ levels by 27%. Conclusions: Although a large proportion of HTLV-1 carriers produced high levels of pro-inflammatory cytokines similar to those observed in HAM/TSP patients, immune response can be downregulated by cytokines or cytokine antagonists in most HTLV-1 carriers. This modulation can be an important step in the prevention of tissue damage and progression from the HTLV-1 carrier state to HAM/TSP.
Description: Texto completo: acesso restrito. p. 145–151
URI: http://repositorio.ufba.br/ri/handle/ri/14746
ISSN: 1021-7401
Appears in Collections:Artigos Publicados em Periódicos (ICS)

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