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Please use this identifier to cite or link to this item: http://repositorio.ufba.br/ri/handle/ri/14491

Title: Schistosoma mansoni infection is associated with a reduced course of asthma
Other Titles: Journal of Allergy and Clinical Immunology
Authors: Medeiros Junior, Manoel
Figueiredo, Joanemile Pacheco de
Almeida, Maria Cecília Freitas de
Matos, Maria Analia
Araujo, Maria Ilma Andrade Santos
Cruz Filho, Álvaro Augusto Souza da
Atta, Ajax Mercês
Rêgo, Marco Antônio Vasconcelos
Jesus, Amélia Maria Ribeiro de
Taketomi, Ernesto Akio
Carvalho Filho, Edgar Marcelino de
Keywords: Asthma;Skin prick test;Dust mites;Helminths;Schistosoma mansoni;IL-10;IgE
Issue Date: 2003
Abstract: Background: Helminthic infections decrease skin reactivity to indoor allergens, but data on whether they influence asthma severity are lacking. Objective: This study evaluated the course of asthma in patients with and without Schistosoma mansoni infection. Methods: Asthmatic subjects were enrolled from 3 low-socioeconomic areas: a rural area endemic for schistosomiasis (group 1) in addition to a rural area (group 2) and a slum area (group 3), both of which were not endemic for schistosomiasis. A questionnaire on the basis of the International Study of Asthma and Allergies in Childhood study was applied in these 3 areas, and from each area, 21 age- and sex-matched asthmatic subjects were selected for a prospective 1-year study. Pulmonary function tests, skin prick tests with indoor allergens, stool examinations, and serum evaluations were performed in these subjects. Every 3 months, the subjects were evaluated for asthma exacerbation through physical examination, and a questionnaire regarding asthma symptoms and use of antiasthma medicine was administered. Results: The prevalence of S mansoni infection was greater in group 1 compared with in groups 2 and 3 (P < .0001), whereas the frequency of other helminth and protozoa infections was similar among the 3 groups. The frequency of positive skin test responses to indoor allergens was less (19.0%) in group 1 subjects relative to those in group 2 (76.2%) and group 3 (57.1%; P < .001). The frequencies of symptoms, use of antiasthma drugs, and pulmonary abnormal findings at physical examination were less in group 1 subjects than in group 2 and 3 subjects (P = .0001). Conclusion: Our results suggest that S mansoni infection is associated with a milder course of asthma.
Description: Texto completo: acesso restrito. p. 947–951
URI: http://repositorio.ufba.br/ri/handle/ri/14491
ISSN: 0091-6749
Appears in Collections:Artigos Publicados em Periódicos (Medicina)

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