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|Title: ||Long lasting BCG protection against leprosy|
|Other Titles: ||Vaccine|
|Authors: ||Rodrigues, Laura Cunha|
Kerr, Ligia Regina Franco Sansigolo
Frietas, Max Victor Carioca
Barreto, Mauricio Lima
|Keywords: ||BCG vaccine;Leprosy;Waning of protection;Duration of protection;Vaccine efficacy|
|Issue Date: ||2007|
|Abstract: ||Background: BCG vaccine protects against leprosy.
Objectives: Estimate BCG protection against leprosy by age by age.
Methods: A case control study with 226 cases of leprosy and 857 controls. BCG vaccination was ascertained via examination of BCG scars. Protection is presented for three age groups.
Results: BCG protection against leprosy was 86% (95% CI: 77–92%) in the age group 18–29; 54% (95% CI: −37% to 85%) in the age group 30–39 and 32% (95% CI: −3% to 56%) in those aged 40 or more.
Conclusions: BCG efficacy against leprosy may well last for three decades and possibly even longer. BCG vaccination must have contributed to worldwide reduction in leprosy incidence.|
|Description: ||Texto completo: acesso restrito. p. 6842-6844|
|Appears in Collections:||Artigos Publicados em Periódicos Estrangeiros (ISC)|
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