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Please use this identifier to cite or link to this item: http://repositorio.ufba.br/ri/handle/ri/14208

Title: Association of TGF-β1 codon 25 (G915C) polymorphism with hepatitis C virus infection
Other Titles: Journal of Medical Virology
Authors: Pereira, Fernanda Albuquerque
Silva, Naize Nara Pinheiro da
Rodart, Itatiana Ferreira
Carmo, Theomira Mauadie Azevedo
Lemaire, Denise Carneiro
Reis, Mitermayer Galvão
Keywords: Hepatitis C;Genes;Cytokines;Polymorphism (genetics)
Issue Date: 2008
Abstract: Cytokines play a key role in the regulation of immune responses. In hepatitis C virus infection (HCV), the production of abnormal cytokine levels appears to contribute to the progression of the disease, viral persistence, and affects response to therapy. Cytokine genes are polymorphic at specific sites, and certain polymorphisms located within coding/regulatory regions have been shown to affect the overall expression and secretion of cytokines. The aim of the present study was to identify potential markers of cytokines genes associated with the susceptibility to HCV infection. The cohort was composed of 128 individuals infected by HCV and 94 healthy controls. Genotyping was carried out by PCR-SSP. The distributions of the following polymorphisms were compared in these groups: TNF-α (−308G/A [rs1800629]), TGF-β1 (codon 10 T/C [rs1982073], codon 25 G/C [rs1800471]), IL-10 (−1082 A/G [rs 1800896]; −819T/C [rs1800871]; −592A/C [rs 1800872]), IL-6 (−174G/C [rs1800795]), and IFN-γ (+874T/A [rs2430561]). This study demonstrated a statistically significant difference in the frequency of TGF-β1 codon 25 polymorphism between healthy subjects and those infected with HCV. No associations were observed between polymorphisms of TNF-α, IFN-γ, IL-10, TGF-β1 codon 10, and IL-6 and HCV infection. These findings suggest that TGF-β1 codon 25 polymorphism could be a host genetic factor associated with susceptibility to HCV infection.
Description: Texto completo: acesso restrito. p. 58-64
URI: http://repositorio.ufba.br/ri/handle/ri/14208
ISSN: 0146-6615
Appears in Collections:Artigos Publicados em Periódicos (ICS)

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