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Please use this identifier to cite or link to this item: http://repositorio.ufba.br/ri/handle/ri/13490

Title: Prevalence of hepatitis C virus infection and HCV genotypes among hemophiliacs in the State of Bahia, Northeastern Brazil: analysis of serological and virological parameters
Other Titles: Revista da Sociedade Brasileira de Medicina Tropical
Authors: Paraná, Raymundo
Reis, Galvão dos
Silva, Luciano Kalabric
Silva, Maria Betânia Souza da
Lopes, Gisele Barreto
Rodart, Itatiana Ferreira
Costa, Fernando Quadros
Santana, Nelma Pereira de
Santana, Aurelino
Keywords: Hepatitis C virus;Hemophilia;Prevalence;Genotype;Bahia
Issue Date: 2005
Abstract: The objective of the present study was to analyze HCV serological and virological parameters from hemophiliacs in the State of Bahia. Anti-HCV was investigated by ELISA in a cohort of 268 hemophiliacs A/B who were followed-up in a reference unit for hemotherapy in the State of Bahia. HCV viremia and genotypes were also determined from a subset of 66 anti-HCV seropositive hemophiliacs. Seroprevalence among hemophiliacs was 42.2% (95% CI 36.5-48.1) and was significantly higher (p<0.05) according to age >10 years, presence of factor VIII/IX inhibitory antibodies and other infection markers. None of the hemophiliacs less than 5 years of age were anti-HCV seropositive. Viremia was detectable in 77.3% (51/66). HCV genotype 1 (74%) was the most prevalent followed by genotype 3 (22%) and genotype 2 (4%). Our results indicate that HCV prevalence is still high among hemophiliacs, although HCV transmission was not observed in young hemophiliacs.
Description: p.496-502
URI: http://repositorio.ufba.br/ri/handle/ri/13490
ISSN: 0037-8682
Appears in Collections:Artigos Publicados em Periódicos (Medicina)

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