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Please use this identifier to cite or link to this item: http://repositorio.ufba.br/ri/handle/ri/13325

Title: Lack of effect of nucleotide-supplemented infant formula on the management of acute diarrhea in infants
Other Titles: Nutrition Research
Authors: Neri, Daniela Almeida
Mattos, Ângela Peixoto de
Ribeiro, Tereza Cristina Medrado
Mendes, Patrícia Silva de Almeida
Valois, Sandra Santos
Ribeiro Jr., Hugo da Costa
Keywords: Acute diarrhea;Children;Nucleotides;Nutritional management;Infant formula
Issue Date: 2009
Abstract: Nucleotides have been identified as conditionally essential nutrients. As prevention studies, conducted with nucleotide-supplemented formula, have shown statistically significant decrease in the risk of diarrhea, we tested the hypothesis that the consumption of nucleotide-supplemented formula during an acute diarrhea episode is associated with therapeutic effects in the treatment of infants with acute diarrhea and dehydration. A randomized, double-blind, controlled clinical trial was conducted in which patients were randomly assigned to 1 of 2 treatment groups. The “test” group consumed a nucleotide-supplemented infant formula and the “control” group consumed a nonsupplemented formula. Infants were accommodated in a metabolic unit where body weight, and all intakes and outputs were recorded at 24-hour intervals during hospitalization. Laboratory parameters including blood gases and electrolytes were monitored during hospitalization. Eighty-one male infants ranging in age from older than 1 month and younger than 1 year, with acute non-cholera diarrhea and dehydration were studied. Primary outcomes were stool output and duration of diarrhea and did not differ significantly between the groups, with a stool output of 304.2 (SD 254.0) vs 350.3 (SD 269.1) g/kg and a duration of diarrhea of 83.3 (SD 44.5) vs 88.8 (SD 46.6) for the test and control groups, respectively. Anemia was highly prevalent and breast-feeding practice was not frequent in both groups. The average energy intake and weight gain were similar in the 2 groups. This study demonstrated that nucleotide supplementation of infant formula during episodes of acute diarrhea has no therapeutic advantage compared to conventional infant formula.
Description: Texto completo: acesso restrito. p. 244-247
URI: http://repositorio.ufba.br/ri/handle/ri/13325
ISSN: 0271-5317
Appears in Collections:Artigos Publicados em Periódicos (Medicina)

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