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Please use this identifier to cite or link to this item: http://repositorio.ufba.br/ri/handle/ri/12720

Title: Anti-leishmanial ige antibodies: a marker of active disease in visceral leishmaniasis
Other Titles: The American Society of Tropical Medicine and Hygiene
Authors: Atta, Ajax Mercês
D'Oliveira Junior, Argemiro
Correa, Jefferson
Atta, Maria Luiza Brito de Sousa
Almeida, Roque Pacheco de
Carvalho Filho, Edgar Marcelino de
Keywords: Leishmaniose visceral
Issue Date: 1998
Publisher: The American Society of Tropical Medicine and Hygiene
Abstract: Abstract. Visceral leishmaniasis (VL) is characterized by a depression of the T helper cell type 1 immune response. Although mRNA expression for interleukin-4 (IL-4) is observed, evidence of the role of this cytokine in the pathogenesis of VL has been lacking. Since IL-4 is involved in IgE synthesis, we measured the total IgE and Leishmania antigen-specific IgE antibody levels in sera from patients with VL. Specific IgE antibodies detected by an ELISA technique after absorbing the sera with purified sheep IgG anti-human IgG were found in all 23 patients with VL and were not detected in subjects with subclinical Leishmania chagasi infection (n 5 10), Chagas’ disease (n 5 10), atopic patients (n 5 10), and healthy controls (n 5 10). Levels of Leishmania-specific IgE (optical density values) before and after treatment were 0.100 6 0.03 (mean 6 SD) and 0.028 6 0.002, respectively (P , 0.05). These results indicate that a specific IgE response is useful in the diagnosis of active disease and to evaluate response to treatment.
Description: p. 426–430
URI: http://www.repositorio.ufba.br/ri/handle/ri/12720
Appears in Collections:Artigos Publicados em Periódicos (FARMACIA)

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