DSpace

RI UFBA >
Instituto de Saúde Coletiva - ISC >
Artigos Publicados em Periódicos Estrangeiros (ISC) >

Please use this identifier to cite or link to this item: http://repositorio.ufba.br/ri/handle/ri/11948

Title: Environmental conditions, immunologic phenotypes, atopy, and asthma: New evidence of how the hygiene hypothesis operates in Latin America
Other Titles: Journal of Allergy and Clinical Immunology
Authors: Figueiredo, Camila Alexandrina
Amorim, Leila Denise Alves Ferreira
Alcântara-Neves, Neuza Maria
Matos, Sheila Maria Alvim de
Cooper, Philip J.
Rodrigues, Laura C.
Barreto, Mauricio Lima
Keywords: LCA;environment;infections;immune phenotypes;children;hygiene hypothesis;SCAALA
Issue Date: 2013
Publisher: Journal of Allergy and Clinical Immunology
Abstract: Background It has been proposed that improved hygiene and reduced experience of infections in childhood influences the development of allergic diseases. The mechanisms by which the hygiene operates are not well established but are underpinned by two apparently incompatible immunologic paradigms, the balance of TH1 versus TH2 cytokines and IL-10–mediated regulation of TH2 cytokines. Objective This study defined immunologic phenotypes with the use of latent class analysis and investigated their associations with environmental factors, markers of allergy and asthma, in a Latin American population. Methods We studied 1127 children living in urban Brazil. Data on wheeze and environmental exposures were collected with standardized questionnaires. Atopy was measured by specific IgE in serum and skin prick test reactivity to aeroallergens. Cytokines were measured in culture after the stimulation of peripheral blood leukocytes with mitogen. Infections with pathogens were assessed by serology and stool examinations. Children were classified as having high or low burden of infection. Latent class analysis was used to identify immune phenotypes on the basis of cytokine production. Logistic regression was used to evaluate the adjusted effects of environment and burden of infection on the immunologic phenotypes and the effect of the phenotypes on atopy and asthma. Results Three phenotypes were identified, labeled underresponsive, intermediate, and responsive. Children of more educated mothers, living in improved environmental conditions, and with a low burden of infection were significantly more likely to have the responsive phenotype. The responsive phenotype was significantly associated with an increased prevalence of atopy but not asthma. Conclusion Our findings contribute to a better understanding of the immune mechanisms by which the hygiene hypothesis operates in urban Latin America.
Description: Texto completo. Acesso restrito. p. 1064-1068
URI: http://www.repositorio.ufba.br/ri/handle/ri/11948
ISSN: 0091-6749
Appears in Collections:Artigos Publicados em Periódicos Estrangeiros (ISC)

Files in This Item:

File Description SizeFormat
22222222222.pdf151.16 kBAdobe PDFView/Open
View Statistics

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

 

    Universidade Federal da Bahia

Contate-nos. Saiba mais sobre o RI/UFBA