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Use este identificador para citar ou linkar para este item: https://repositorio.ufba.br/handle/ri/8590
Tipo: Artigo de Periódico
Título: Immune responses to T-dependent and T-independent antigens during visceral leishmaniasis in mice: Evidence for altered T-cell regulation of immune responses to non-parasite antigens
Título(s) alternativo(s): Cellular Immunology
Autor(es): Reed, Steven G.
Roters, Silene B.
Inverso, Jill A.
Jones, Thomas C.
Goidl, Edmond A.
Autor(es): Reed, Steven G.
Roters, Silene B.
Inverso, Jill A.
Jones, Thomas C.
Goidl, Edmond A.
Abstract: Antibody responses to T-dependent and T-“independent” antigens were studied in diseasesusceptible (BALB/c and C57BL/lO) and disease-resistant (A/J) mice infected with Leishmania donovani chagasi. Disease-susceptible mice but not disease-resistant mice showed a transient decrease in PFC responses to TNP on a T-dependent carrier (BGG) during the period of 4-8 weeks after infection. Infected disease-susceptible animals also showed increased responses to TNP on a type II T-independent carrier (Ficoll), which persisted until at least 14 weeks after infection. The increased responses were associated with a significant increase in anti-TNP antibody of the lgG2b subclass. When T-enriched spleen cells from infected mice and B-enriched spleen cells from uninfected mice were transferred to irradiated recipients immunized with TNP-Ficoll, increased anti-TNP PFC were observed over numbers seen in irradiated recipients which received both B and T cells from uninfected mice. Increased responses to TNP-Ficoll were also induced by prior administration of soluble leishmania extract in CFA. Infected mice immunized with TNP-LPS, a T-independent type I antigen, also had increased anti-TNP antibody responses, but had normal anti-LPS antibody responses. The elevated antibody production which occurred in response to the T-“independent” antigens could not be attributed to the relatively low polyclonal response which occurred in both disease-resistant and disease-susceptible mice infected with L. donovani chagasi. The observations are consistent with leishmania induced, transient alterations in some T-cell functions including response to haptens on T-dependent carriers, and a lack of down regulation of T-“independent” responses. Subtle lesions in immunoregulation may be important correlates of successful protozoa1 infection and may be responsible for some of the immunologic manifestations of the disease
Editora / Evento / Instituição: Cellular Immunology
URI: http://www.repositorio.ufba.br/ri/handle/ri/8590
Data do documento: 1985
Aparece nas coleções:Artigo Publicado em Periódico (Faculdade de Medicina)

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