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dc.contributor.authorReed, Steven G.-
dc.contributor.authorRoters, Silene B.-
dc.contributor.authorInverso, Jill A.-
dc.contributor.authorJones, Thomas C.-
dc.contributor.authorGoidl, Edmond A.-
dc.creatorReed, Steven G.-
dc.creatorRoters, Silene B.-
dc.creatorInverso, Jill A.-
dc.creatorJones, Thomas C.-
dc.creatorGoidl, Edmond A.-
dc.date.accessioned2013-02-21T13:02:52Z-
dc.date.available2013-02-21T13:02:52Z-
dc.date.issued1985-
dc.identifier.issn0008-8749-
dc.identifier.urihttp://www.repositorio.ufba.br/ri/handle/ri/8590-
dc.descriptionTexto completo. Acesso restrito. p. 12–25pt_BR
dc.description.abstractAntibody responses to T-dependent and T-“independent” antigens were studied in diseasesusceptible (BALB/c and C57BL/lO) and disease-resistant (A/J) mice infected with Leishmania donovani chagasi. Disease-susceptible mice but not disease-resistant mice showed a transient decrease in PFC responses to TNP on a T-dependent carrier (BGG) during the period of 4-8 weeks after infection. Infected disease-susceptible animals also showed increased responses to TNP on a type II T-independent carrier (Ficoll), which persisted until at least 14 weeks after infection. The increased responses were associated with a significant increase in anti-TNP antibody of the lgG2b subclass. When T-enriched spleen cells from infected mice and B-enriched spleen cells from uninfected mice were transferred to irradiated recipients immunized with TNP-Ficoll, increased anti-TNP PFC were observed over numbers seen in irradiated recipients which received both B and T cells from uninfected mice. Increased responses to TNP-Ficoll were also induced by prior administration of soluble leishmania extract in CFA. Infected mice immunized with TNP-LPS, a T-independent type I antigen, also had increased anti-TNP antibody responses, but had normal anti-LPS antibody responses. The elevated antibody production which occurred in response to the T-“independent” antigens could not be attributed to the relatively low polyclonal response which occurred in both disease-resistant and disease-susceptible mice infected with L. donovani chagasi. The observations are consistent with leishmania induced, transient alterations in some T-cell functions including response to haptens on T-dependent carriers, and a lack of down regulation of T-“independent” responses. Subtle lesions in immunoregulation may be important correlates of successful protozoa1 infection and may be responsible for some of the immunologic manifestations of the diseasept_BR
dc.language.isoenpt_BR
dc.publisherCellular Immunologypt_BR
dc.sourcehttp://dx.doi.org/10.1016/0008-8749(85)90336-3pt_BR
dc.titleImmune responses to T-dependent and T-independent antigens during visceral leishmaniasis in mice: Evidence for altered T-cell regulation of immune responses to non-parasite antigenspt_BR
dc.title.alternativeCellular Immunologypt_BR
dc.typeArtigo de Periódicopt_BR
dc.description.localpubSalvadorpt_BR
dc.identifier.numberv. 96, n. 1pt_BR
Aparece nas coleções:Artigo Publicado em Periódico (Faculdade de Medicina)

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