https://repositorio.ufba.br/handle/ri/7745
Tipo: | Artigo de Periódico |
Título: | Assessment of the serodiagnostic potential of nine novel proteins from Mycobacterium tuberculosis |
Título(s) alternativo(s): | FEMS Microbiology Letters |
Autor(es): | Moran, Alison J. Treit, Janice D. Whitney, Janice L. Abomoelak, Bassam Sampaio, Diana Pedral Badaró, Roberto José da Silva |
Autor(es): | Moran, Alison J. Treit, Janice D. Whitney, Janice L. Abomoelak, Bassam Sampaio, Diana Pedral Badaró, Roberto José da Silva |
Abstract: | To identify antigens that would improve the accuracy of serological diagnosis of active tuberculosis, we cloned the genes encoding nine potentially immunogenic secreted or surface-associated proteins of Mycobacterium tuberculosis. Recombinant proteins were reacted with sera from HIV-negative individuals with extrapulmonary tuberculosis (EP-TB) or HIV-positive individuals with pulmonary tuberculosis (TBH). Specific and high level antibody responses were obtained for four recombinant proteins, of which antigen GST-822 was recognized by 60% of EP-TB and 42% of TBH and antigen MBP-506 was recognized by 45% of EP-TB and 61% of TBH. These results suggest that these proteins are strong candidates as subunits in a polyvalent serodiagnostic test. |
Palavras-chave: | Serodiagnosis Tuberculosis Antigen |
URI: | http://www.repositorio.ufba.br/ri/handle/ri/7745 |
Data do documento: | 2001 |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina) |
Arquivo | Descrição | Tamanho | Formato | |
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Moran.pdf Restricted Access | 243,87 kB | Adobe PDF | Visualizar/Abrir Solicitar uma cópia |
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