Correlação das citocinas il2, il10 e tgf-β com o desfecho clínico de pacientes com COVID-19 admitidos em unidade de terapia intensiva

Abstract

he coronavirus epidemic, called SARS-CoV-2, emerged in December 2019 in the city of Wuhan in China. The infection spread rapidly to other regions of the country and around the world. In March 2020, the WHO recognized COVID-19 as a pandemic and published a series of measures aimed at minimizing the spread, infection, and risk of collapse of the global health system. SARS-Cov-2 belongs to the Coronaviridae family, order Nidovirales, and is an enveloped virus that contains a single strand of RNA. Clinical manifestations range from mild to severe cases. The lungs are the main organs affected by SARS-CoV-2, mainly affected by the dysregulation of innate and acquired immune responses, promoting a cytokine storm, responsible for inducing a process of hyperinflammation, becoming one of the main causes of death. Therefore, the objective of this study was to evaluate the correlation of cytokines in the Treg response (IL2, IL10, and TGF-β) with the clinical outcome of patients with COVID-19. The study consisted of 56 patients admitted to an intensive care unit. Serum samples were obtained from blood samples and subsequently analyzed by the ELISA method using specific kits for each cytokine. After the study and statistical applications, the variables TGF-β and IL2 showed strong positive correlations with the outcome of death, while IL10 showed a moderate negative correlation with the outcome of death. The above helps us to better understand the mechanisms that influence the development of the severe stage of the disease so that we can develop and establish effective methods of controlling and understanding the pathology.