https://repositorio.ufba.br/handle/ri/15962
metadata.dc.type: | Artigo de Periódico |
Título : | Immunohistochemical detection of Langerhans cells in dental granulomas and radicular cysts |
Otros títulos : | Journal of Molecular Histology |
Autor : | Santos, Luciano Cincurá Silva Ramos, Eduardo Antônio Gonçalves Gurgel, Clarissa Araújo Silva Santana, Edmar José Borges de Santos, Jean Nunes dos |
metadata.dc.creator: | Santos, Luciano Cincurá Silva Ramos, Eduardo Antônio Gonçalves Gurgel, Clarissa Araújo Silva Santana, Edmar José Borges de Santos, Jean Nunes dos |
Resumen : | Objective: Dental granulomas (DGs) and radicular cysts (RCs) are chronic periapical lesions frequently involving the jaws. Langerhans cells (LCs) are dendritic cells responsible for the presentation of antigens to T lymphocytes. This study examined the expression of LCs in DG and RCs by immunohistochemical staining. Study Design: Eighteen cases of DGs and 26 cases of RCs were analyzed using anti-CD1a marker. Results: CD1a-labeled LCs were observed in 11.1% of DGs and in 69.2% of RCs, showing a significant correlation (P < 0.0001; Fisher’s test). In DGs, LCs were only observed in granulation tissue, showing discrete immunostaining density. In RCs, LCs exhibited both a round and a dendritic shape in all epithelial layers. Although a correlation was observed between immunostaining density and epithelial thickness, as well as between immunostaining and inflammatory intensity, the differences were not significant in radicular cysts. Conclusion: Langerhans cells provide important insight into the immunopathogenesis of chronic periapical lesions. |
Palabras clave : | Radicular cyst Dental granuloma Immunohistochemistry Langerhans cell |
metadata.dc.rights: | Acesso Aberto |
URI : | http://repositorio.ufba.br/ri/handle/ri/15962 |
Fecha de publicación : | 2007 |
Aparece en las colecciones: | Artigo Publicado em Periódico (Faculdade de Odontologia) |
Fichero | Descripción | Tamaño | Formato | |
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art%3A10.1007%2Fs10735-007-9088-3.pdf | 199,68 kB | Adobe PDF | Visualizar/Abrir |
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