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metadata.dc.type: | Artigo de Periódico |
Title: | In vivo protective effect of the lectin from Canavalia brasiliensis on BALB/c mice infected by Leishmania amazonensis_0 |
Other Titles: | Acta Tropica |
Authors: | Barral-Netto, Manoel Sohsten, R. L. Von Teixeira, M. Santos, Washington Luis Conrado dos Pompeu, M. L. Moreira, R. A. Oliveira, J. T. A. Cavada, B. S. Falcoff, E. Barral, Aldina Maria Prado |
metadata.dc.creator: | Barral-Netto, Manoel Sohsten, R. L. Von Teixeira, M. Santos, Washington Luis Conrado dos Pompeu, M. L. Moreira, R. A. Oliveira, J. T. A. Cavada, B. S. Falcoff, E. Barral, Aldina Maria Prado |
Abstract: | In vivo administration of Canavalia brasiliensis lectin (at the time of infection, or maintained throughout the infection) reduced the lesions of highly susceptible BALB/c mice infected by Leishmania amazonensis. At the doses used C. brasiliensis lectin (ConBr) does not interfere with penetration or fate of Leishmania in the macrophages in vitro. Since Interferon-γ (IFN-γ) is the major macrophage activating factor, and considered a critical element in the successful immune response against leishmaniasis, we explored its participation in this phenomenon. ConBr either in vivo or in vitro induced IFN-γ production in normal or in leishmania-infected BALB/c mice. However we were unable to change the course of disease by in vivo IFN-γ administration (although IFN-γ preparations were effective in inducing a leishmanicidal effect in vitro on L. amazonensis-infected peritoneal macrophages). Additionally, IFN-γ neutralization with anti-IFN-γ monoclonal antibody did not alter the protection conferred by ConBr administration. These data show that lectin administration in vivo is protective in the otherwise unchecked L. amazonensis infection of BALB/c mice, and suggest that such effect is not mediated by IFN-γ. |
Keywords: | Leishmania amazonensis Leishmaniasis Leishmania Tegumentary leishmaniasis Experimental leishmaniasis Canavalia brasiliensis Interferon-γ |
Publisher: | Acta Tropica |
URI: | http://www.repositorio.ufba.br/ri/handle/ri/12895 |
Issue Date: | 1996 |
Appears in Collections: | Artigo Publicado em Periódico Estrangeiro (ISC) |
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