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metadata.dc.type: | Artigo de Periódico |
Title: | Outbreak of Aseptic Meningitis associated with Mass Vaccination with a Urabe-containing Measles-Mumps-Rubella Vaccine |
Other Titles: | American Journal of Epidemiology |
Authors: | Dourado, Maria Inês Costa Cunha, Sergio Teixeira, Maria da Glória Lima Cruz Farrington, C. Paddy Melo, Ailton de Souza Lucena, Rita de Cássia Saldanha de Barreto, Mauricio Lima |
metadata.dc.creator: | Dourado, Maria Inês Costa Cunha, Sergio Teixeira, Maria da Glória Lima Cruz Farrington, C. Paddy Melo, Ailton de Souza Lucena, Rita de Cássia Saldanha de Barreto, Mauricio Lima |
Abstract: | A mass immunization campaign with a Urabe-containing measles-mumps-rubella vaccine was carried out in 1997 in the city of Salvador, northeastern Brazil, with a target population of children aged 1-11 years. There was an outbreak of aseptic meningitis following the mass campaign. Cases of aseptic meningitis were ascertained through data collected from the records of children admitted to the local referral hospital for infectious diseases between March and October of 1997, using previously defined eligibility criteria. Vaccination histories were obtained through home visits or telephone calls. Eighty-seven cases fulfilled the study criteria. Of those, 58 cases were diagnosed after the vaccination campaign. An elevated risk of aseptic meningitis was observed 3 weeks after Brazil's national vaccination day compared with the risk in the prevaccination period (relative risk = 14.3; 95% confidence interval: 7.9, 25.7). This result was confirmed by a case series analysis (relative risk = 30.4; 95% confidence interval: 11.5, 80.8). The estimated risk of aseptic meningitis was 1 in 14,000 doses. This study confirms a link between measles-mumps-rubella vaccination and aseptic meningitis. The authors discuss the implications of this for the organization and planning of mass immunization campaigns. Am J Epidemiol 2000;151:524-30. |
Keywords: | disease outbreaks meningitis aseptic mumps vaccine product surveillance postmarketing vaccines |
Publisher: | American Journal of Epidemiology |
URI: | http://www.repositorio.ufba.br/ri/handle/ri/12325 |
Issue Date: | 2000 |
Appears in Collections: | Artigo Publicado em Periódico Estrangeiro (ISC) |
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