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Antinociceptive Properties of Physalins from Physalis angulata

Wed, 01 Jan 2014 00:00:00 GMT

Título: Antinociceptive Properties of Physalins from Physalis angulata Autor(es): Lima, Milena da Silva; Evangelista, Afrânio Ferreira; Santos, Gisele Graça Leite dos; Ribeiro, Ivone Maria; Tomassini, Therezinha Coelho Barbosa; Soares, Milena Botelho Pereira; Villarreal, Cristiane Flora Abstract: Pain is the most common reason a patient sees a physician. Nevertheless, the use of typical painkillers is not completely effective in controlling all pain syndromes; therefore further attempts have been made to develop improved analgesic drugs. The present study was undertaken to evaluate the antinociceptive properties of physalins B (1), D (2), F (3), and G (4) isolated from Physalis angulata in inflammatory and centrally mediated pain tests in mice. Systemic pretreatment with 1–4 produced dose-related antinociceptive effects on the writhing and formalin tests, traditional screening tools for the assessment of analgesic drugs. On the other hand, only 3 inhibited inflammatory parameters such as hyperalgesia, edema, and local production of TNF-α following induction with complete Freund’s adjuvant. Treatment with 1, 3, and 4 produced an antinociceptive effect on the tail flick test, suggesting a centrally mediated antinociception. Reinforcing this idea, 2–4 enhanced the mice latency reaction time during the hot plate test. Mice treated with physalins did not demonstrate motor performance alterations. These results suggest that 1–4 present antinociceptive properties associated with central, but not anti-inflammatory, events and indicate a new pharmacological property of physalins. Tipo: Artigo de Periódico

Incorporação de urucum como aditivo antioxidante em embalagens biodegradáveis a base de quitosana

Tue, 01 Jan 2013 00:00:00 GMT

Título: Incorporação de urucum como aditivo antioxidante em embalagens biodegradáveis a base de quitosana Autor(es): Santana, Maria Cecília Castelo Branco de; Machado, Bruna Aparecida Souza; Silva, Tamara do Nascimento da; Nunes, Itaciara Larroza; Druzian, Janice Izabel Abstract: The objective was to develop and characterize a biodegradable packaging using chitosan as polymeric matrix, plasticized with glycerol, as well as evaluate the effect of adding a natural antioxidant additives (annatto) in antioxidant protection in packaging. The cans were prepared by casting containing 1.5% of chitosan, 0.15% glycerol and 0.25 to 1.0% of coloring. Palm oil packed with the fi lms containing the additive was monitored at 0, 7, 15, 30 and 45 days of storage under accelerated oxidation conditions (63% UR/30ºC). Palm oil packed in the fi lm that contained the highest percentage of annatto (1.0%) was the least oxidized during the study period. It was found that, as they increase the losses of phenolic compounds in the formulations of the fi lms, there is a reduction in the peroxide increases the packaged product, thus demonstrating that instead of the product, the compounds of the package’s who are suffering oxidation. Tipo: Artigo de Periódico

Evidence for the Involvement of Descending Pain-Inhibitory Mechanisms in the Antinociceptive Effect of Hecogenin Acetate

Tue, 01 Jan 2013 00:00:00 GMT

Título: Evidence for the Involvement of Descending Pain-Inhibitory Mechanisms in the Antinociceptive Effect of Hecogenin Acetate Autor(es): Gama, Kelly Barbosa; Quintans, Jullyana de Souza Siqueira; Antoniolli, Ângelo Roberto; Quintans Júnior, Lucindo José; Santana, Wagno Alcântara de; Branco, Alexsandro; Soares, Milena Botelho Pereira; Villarreal, Cristiane Flora Abstract: Hecogenin is a sapogenin present in the leaves of species from the Agave genus, with a wide spectrum of reported pharmacological activities. The present study was undertaken to evaluate whether hecogenin acetate (1) has antinociceptive properties and to determine its mechanism of action. The nociceptive threshold was evaluated using the tail flick test in mice. Mice motor performance was evaluated in a Rotarod test. By using Fos expression as a marker of neural activation, the involvement of the periaqueductal gray in 1-induced antinociception was evaluated. Intraperitoneal administration of 1 (5–40 mg/kg) produced a dose-dependent increase in the tail flick latency time compared to vehicle-treated group (p < 0.01). Mice treated with 1 (40 mg/kg) did not show motor performance alterations. The antinociception of 1 (40 mg/kg) was prevented by naloxone (nonselective opioid receptor antagonist; 5 mg/kg), CTOP (μ-opioid receptor antagonist; 1 mg/kg), nor-BNI (κ-opioid receptor antagonist; 0.5 mg/kg), naltrindole (δ-opioid receptor antagonist; 3 mg/kg), or glibenclamide (ATP-sensitive K+ channel blocker; 2 mg/kg). Systemic administration of 1 (5–40 mg/kg) increased the number of Fos positive cells in the periaqueductal gray. The present study has demonstrated for the first time that 1 produces consistent antinociception mediated by opioid receptors and endogenous analgesic mechanisms. Tipo: Artigo de Periódico

Bioactive Oleanane, Lupane and Ursane Triterpene Acid Derivatives

Sun, 01 Jan 2012 00:00:00 GMT

Título: Bioactive Oleanane, Lupane and Ursane Triterpene Acid Derivatives Autor(es): Silva, Maria de L. e; David, Juceni Pereira de Lima; Silva, Lidércia C. R. C.; Santos, Rauldenis Almeida Fonseca; David, Jorge Mauricio; Lima, Luciano S.; Reis, Pedro S.; Fontana, Renato Abstract: Betulinic, ursolic and oleanolic acids isolated from the aerial parts of Eriope blanchetii (Lamiaceae) were subjected to different esterification reactions, yielding 12 C-3 position ester derivatives. All compounds were identified using spectroscopic techniques, such as IR, 1H-NMR and MS. The derivatives were further investigated for their antioxidant level, Artemia salina lethality and antimicrobial activity. Tipo: Artigo de Periódico