https://repositorio.ufba.br/handle/ri/10072 Sun, 03 May 2026 05:40:06 GMT 2026-05-03T05:40:06Z https://repositorio.ufba.br/handle/ri/43151 Título: Variabilidade na percepção de cuidados paliativos e cuidados de fim de vida entre profissionais de hematologia de um mesmo centro de referência na Bahia, Brasil: um estudo de corte transversal Autor(es): Miranda, Diego Lopes Paim Primeiro Orientador: Araújo, Marco Aurélio Salvino de Abstract: Introduction: Several illness-specific cultural and system-based barriers to palliative care (PC) integration and optimal end-of-life (EOL) care exist in the oncohematology scenario. Limited research exists exploring determinants of the discrepancies in daily implementation of PC among healthcare professionals in this field. Objective: We aimed to investigate the variability in PC and EOL care among hematologists and hematology residents at the hematology service of Clinics Hospital of the Federal University of Bahia (UFBA). Methods: Cross-sectional study performed between October and December 2022. Variables were collected through a sociodemographic questionnaire and an adaptation of clinical questionnaires used in previous studies. Results: During the research period, all twenty physicians from the hematology division of the Clinics Hospital of the UFBA participated. Median age was 44 years-old, with 80% of participants identifying as female and 75% were graduated hematologists. Participants were presented with a hypothetical scenario involving the treatment of a 65-year-old female patient with poor prognosis acute myeloid leukemia refractory to first-line treatment. Sixty percent of participants chose to follow other chemotherapy regimens, while 40% implemented PC. Participants next considered a case salvage for the patient who developed septic shock following chemotherapy and were prompted to choose their most probable conduct and the conduct they thought would be better for the patient. Even though being part of the same center, we found a divergence from the most probable conduct among 40% of participants. Reasons involved personal convictions, legal aspects and other physicians’ reactions. Discussion: We found considerable differences within PC decisions between professionals despite being under the same service and protocols. Such investigations hold immense importance for existing literature, as they may identify modifiable factors that can effectively enhance quality of PC and EOL care within the oncohematology setting. Editora / Evento / Instituição: Universidade Federal da Bahia Tipo: Dissertação Thu, 18 Jan 2024 00:00:00 GMT https://repositorio.ufba.br/handle/ri/43151 2024-01-18T00:00:00Z https://repositorio.ufba.br/handle/ri/38266 Título: Conhecimento de pacientes idosos sobre a indicação de medicamentos prescritos Autor(es): Gama, Romana Santos Primeiro Orientador: Passos, Luiz Carlos Santana Abstract: Patient adherence is associated to successful pharmacotherapy; however, many patients do not take their medications as prescribed because of poor understanding of their purpose. To understand how to use the medication correctly, patients need to obtain clear guidelines and instructions, as their behavior and characteristics play a fundamental role in the effectiveness of a medication. Objective: The aim of this study was to evaluate older people’s knowledge of the purpose of drugs prescribed at medical appointments in primary care units and the aspects related to their level of knowledge of their medications. Methods: This was a cross-sectional study conducted in 22 basic health units in Brazil. Older adults who were waiting for medical consultations in the study facilities were interviewed after a consultation with a family practice physician. Data were collected from September 2016 to March 2019. Patients who were ≥ 60 years old who visited the primary care units were included in the study (n = 674). Knowledge of prescribed medications was assessed by comparing the responses to the questionnaire and the medication and prescription information. Multivariate analyses were conducted using a Poisson regression with robust variance. Results: The mean age of the sample was 70.1 (standard deviation ± 7.1) years. Among 674 patients, 272 (40.4%) did not know the indication of at least 1 of their prescribed drugs; among them 78 (11.6%) did not know the indication of any of their prescribed drugs. In the final multivariate analysis, polypharmacy, illiteracy, and cognitive impairment were found to be associated with misunderstanding the purpose of at least 1 prescribed drug. Moreover, illiteracy and cognitive impairment were associated with a greater misunderstanding of the purpose of all prescribed drugs. Conclusion: This study demonstrated that there is a considerable lack of knowledge about prescribed medications among older Brazilian adults after a medical appointment. For this reason, health services and professionals need to implement strategies to improve patient’s knowledge Editora / Evento / Instituição: Universidade Federal da Bahia Tipo: Dissertação Thu, 09 Jun 2022 00:00:00 GMT https://repositorio.ufba.br/handle/ri/38266 2022-06-09T00:00:00Z https://repositorio.ufba.br/handle/ri/38117 Título: Variabilidade do gene S do novo coronavírus em pacientes atendidos no complexo Hospitalar Professor Edgard Santos-UFBA Autor(es): Santos, Felice Deminco Alves Primeiro Orientador: Alves, Carlos Roberto Brites Abstract: Introduction: COVID-19 is a new disease caused by a human coronavirus, whose etiological agent is SARS-CoV-2. Two years have passed and SARS-CoV-2 has a great genetic diversity, which favored the emergence of emergency variants during different periods of the pandemic. Due to the importance employed in viral surveillance and the limitations found in new generation sequencing platforms, the objective of this work was to identify the variability in the Spike region of SARS-CoV2, from a Sanger sequencing platform, in patients with COVID-19 treated at the University Hospital Professor Edgard Santos in Salvador-BA. Methods: This is a cross-sectional observational study with preserved samples, positive for SARS-CoV2, of individuals over 18 years of age, employees, or patients, treated at the Professor Edgard Santos University Hospital (HUPES). All samples from the enrolled participants were confirmed for COVID-19 by an RT-qPCR assay. The extracted viral genetic material was used for a NESTED-PCR assay on the SARS-CoV-2 S gene and the results revealed on a 1.5% agarose gel. The sequencing reaction using the BigDye Terminator V3.1 Cycle Senquencing kit was performed in a region of 1,120 base pairs and the result of this reaction was read by the SeqStudio capillary electrophoresis machine. The files of sequences generated by the machine were analyzed for the construction of the consensus sequence from the reference sequence and identification of mutations throughout the genome. Results: Of all 103 sequenced samples, 69 contained relevant variants represented by 20 BA.1, 13 delta, 22 gamma and 14 zeta, identified between June 2020 and February 2022. All sequences found were aligned with sequences representative of the variants. Conclusions: The protocol developed by this work was able to identify and monitor the variability of the SARS-CoV-2 S gene and, consequently, identify the most relevant variants for the pandemic, which could be an alternative methodology for viral molecular surveillance. Editora / Evento / Instituição: Universidade Federal da Bahia Tipo: Dissertação Mon, 12 Dec 2022 00:00:00 GMT https://repositorio.ufba.br/handle/ri/38117 2022-12-12T00:00:00Z https://repositorio.ufba.br/handle/ri/34691 Título: Grau de risco de ulceração e reulceração do pé Diabético e fatores associados Autor(es): Lopes, Cícero Fidelis Primeiro Orientador: Rêgo, Marco Antônio Vasconcelos Abstract: RISK DEGREE OF ULCERATION AND REULCERATION OF THE DIABETIC FOOT AND ASSOCIATED FACTORS Introduction: Lower limb amputations in diabetics are related significantly with the presence of foot consultation. Early identification of changes that preceding the consultation allows the adoption of therapeutic and preventive measures that can reduce the occurrence of ulceration and, consequently, amputation. Objectives: Describe the distribution of the degree of risk of diabetic foot and associated factors in patients from one center reference in the treatment of diabetes mellitus (DM). Material and methods: Study cross-sectional with 309 with DM included, selected in the outpatient clinics of the State Reference Center for Diabetes Care and Endocrinology da Bahia), being analyzed the following variables: risk of ulceration and reulceration (UR); socio-demographics; difficulties regarding the use of shoes; related to foot care and changes in physical examination of the feet. Results: About 20% of the were classified at risk of RU. The following associations were observed for means of logistics and prevalence ratio (PR): between the degree of RU prevalence and the presence of callus and interdigital skin maceration; between family income less than three shopping and callus; between time of DM ≥ 10 years and interdigital skin maceration; in between DM ≥ 10 years, sex, schooling and degree of risk of RU. Conclusion: The results can contribute to the review and improvement of diabetic foot care and serve as a basis for prospective study on UR insufficiency and associated factors Editora / Evento / Instituição: Universidade Federal da Bahia Tipo: Dissertação Sat, 01 Jan 2011 00:00:00 GMT https://repositorio.ufba.br/handle/ri/34691 2011-01-01T00:00:00Z