Associação da circunferência do braço com níveis séricos de Proteína C Reativa e com polimorfismos de traços antropométricos em indivíduos com Síndrome Metabólica

Abstract

Introduction: Metabolic Syndrome (MS) is a complex disorder that includes abdominal obesity, associated with other cardiovascular and inflammatory risk factors such as CReactive Protein (CRP). Excess subcutaneous adipose tissue (which can be measured by middle upper arm circumference - MUAC) can increase inflammation and consequently cardiovascular risk in people with MS. In this sense, it is important to verify the association between MUAC and CRP (article 1); and whether genetic polymorphisms linked to anthropometric parameters can be used as a way to predict obesity in individuals with MS (article 2). Methods: This is a cross-sectional study with a quantitative approach with adults of both sexes with MS. Two studies were carried out. At first (article 1), MUAC, parameters for the diagnosis of MS (fasting glucose, HDL-c, triglycerides, blood pressure and waist circumference - WC), CRP, other indicators of cardiovascular risk were measured (conicity index and waist-to-height ratio) and body mass index (BMI) of patients, in order to verify the correlation between MUAC and the aforementioned parameters. Second (article 2), five polymorphisms (rs4081724, rs12446632, rs11847697, rs11583200 and rs17405819) were selected to identify the association between such polymorphisms and MUAC and the parameters for the diagnosis of MS. Genotyping of SNPs was performed by TaqMan assay technology. Data were analyzed by the SPSS ver 20.0 and the adequacy of genotypic frequencies of polymorphisms through the Arlequin ver 2000. Results: The study population was mostly female (84%); adult (60.5%); of black skin color (57.1%); and with high cardiovascular risk according to CRP (49.4%). An association was found between MUAC and serum CRP levels and crude multivariate logistic regression showed that each cm of MUAC increased by 10% the chance of presenting high cardiovascular risk according to CRP. According to the current classification of the MUAC, only 19% of the individuals studied were obese. No polymorphism evaluated was associated with MUAC and BMI, and among the polymorphisms studied, only rs17405819 was correlated with triglycerides andrs11847697 with diastolic blood pressure. Conclusion: MUAC was associated with serum CRP levels in individuals with MS, however, the genetic polymorphisms studied in this work were not able to show a correlation with anthropometric and clinical parameters.