Use este identificador para citar ou linkar para este item:
https://repositorio.ufba.br/handle/ri/16448
Registro completo de metadados
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Leite, Márcio Rios | - |
dc.contributor.author | Santos, Sandra Sousa | - |
dc.contributor.author | Lyra, André Castro | - |
dc.contributor.author | Mota, Jaciane | - |
dc.contributor.author | Santana, Genoile Oliveira | - |
dc.creator | Leite, Márcio Rios | - |
dc.creator | Santos, Sandra Sousa | - |
dc.creator | Lyra, André Castro | - |
dc.creator | Mota, Jaciane | - |
dc.creator | Santana, Genoile Oliveira | - |
dc.date.accessioned | 2014-10-21T16:47:01Z | - |
dc.date.available | 2014-10-21T16:47:01Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1007-9327 | - |
dc.identifier.uri | http://repositorio.ufba.br/ri/handle/ri/16448 | - |
dc.description | p. 5028-5031 | pt_BR |
dc.description.abstract | Crohn’s disease is a chronic inflammatory disorder of the gastrointestinal tract that is defined by relapsing and remitting episodes. Tumor necrosis factor alpha (TNF-α) appears to play a central role in the pathophysiology of the disease. Standard therapies for inflammatory bowel disease fail to induce remission in about 30% of patients. Biological therapies have been associated with an increased incidence of infections, especially infection by Mycobacterium tuberculosis (Mtb). Thalidomide is an oral immunomodulatory agent with anti-TNF-α properties. Recent studies have suggested that thalidomide is effective in refractory luminal and fistulizing Crohn’s disease. Thalidomide costimulates T lymphocytes, with greater effect on CD8+ than on CD4+ T cells, which contributes to the protective immune response to Mtb infection. We present a case of Crohn’s disease with gastric, ileal, colon and rectum involvement as well as steroid dependency, which progressed with loss of response to infliximab after three years of therapy. The thorax computed tomography scan demonstrated a pulmonary nodule suspected to be Mtb infection. The patient was started on thalidomide therapy and exhibited an excellent response. | pt_BR |
dc.language.iso | en | pt_BR |
dc.rights | Acesso Aberto | pt_BR |
dc.source | http://dx.doi.org/ 10.3748/wjg.v17.i45.5028 | pt_BR |
dc.subject | Anti-tumor necrosis factor alpha | pt_BR |
dc.subject | Crohn’s disease | pt_BR |
dc.subject | Mucosal healing | pt_BR |
dc.subject | Mycobacterium tuberculosis | pt_BR |
dc.subject | Thalidomide | pt_BR |
dc.title | Thalidomide induces mucosal healing in Crohn's disease: Case report | pt_BR |
dc.title.alternative | World Journal of Gastroenterology | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.identifier.number | v. 17 n. 45 | pt_BR |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina) |
Arquivos associados a este item:
Arquivo | Descrição | Tamanho | Formato | |
---|---|---|---|---|
André Castro Lyra.pdf | 744,93 kB | Adobe PDF | Visualizar/Abrir |
Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.