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Campo DC | Valor | Idioma |
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dc.contributor.author | Andrade, Ana Cristina O. | - |
dc.contributor.author | Ladeia, Ana Marice Teixeira | - |
dc.contributor.author | M. Netto, Eduardo M. | - |
dc.contributor.author | Mascarenhas, Amanda | - |
dc.contributor.author | Cotter, Bruno | - |
dc.contributor.author | Benson, Constance A. | - |
dc.contributor.author | Badaró, Roberto José da Silva | - |
dc.creator | Andrade, Ana Cristina O. | - |
dc.creator | Ladeia, Ana Marice Teixeira | - |
dc.creator | M. Netto, Eduardo M. | - |
dc.creator | Mascarenhas, Amanda | - |
dc.creator | Cotter, Bruno | - |
dc.creator | Benson, Constance A. | - |
dc.creator | Badaró, Roberto José da Silva | - |
dc.date.accessioned | 2014-01-28T14:28:00Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0889-2229 | - |
dc.identifier.uri | http://repositorio.ufba.br/ri/handle/ri/14490 | - |
dc.description | Texto completo: acesso restrito. p. 27-33 | pt_BR |
dc.description.abstract | Antiretroviral therapy (ART) in HIV-infected patients has been associated with an increased risk of cardiovascular disease. This study evaluates vascular endothelial dysfunction of the peripheral circulation in Brazilian HIV-infected subjects on ART or naive to ART compared to a control group matched for age and body mass index (BMI). We performed a cross-sectional comparative study to measure postischemic peak flow-mediated dilation (FMD) of the brachial artery and the response to glyceryl trinitrate (GTN) in HIV-infected patients and healthy controls in Salvador, Bahia, Brazil. Endothelial vasomotor function was evaluated by assessing brachial artery FMD. Forty-four HIV-infected individuals (33 ARV treated and 11 ART naive) were compared to 25 healthy controls matched for age and BMI. FMD % was significantly lower for the ART-experienced patients compared to the ART-naive patients and was also significantly different from controls (ART experienced 8.2 ± 6.0% vs. 19.3 ± 4.8% vs. 23.3 ± 6.1%), respectively (p < 0.0001). The cholesterol, triglyceride, and ALT levels were significantly higher in the ART-experienced group compared to the ART-naive and control subjects (p < 0.028); however, linear regression analysis revealed a statistically significant association of endothelial dysfunction as a dependent variable only with ARV treatment in HIV-infected subjects (p = 0.03). The association of endothelial dysfunction with ARV therapy in HIV-infected patients was independent of protease inhibitor-containing regimens or dyslipidemia. This dysfunction may contribute to the risk for HIV-associated atherosclerosis. | pt_BR |
dc.language.iso | en | pt_BR |
dc.rights | Acesso Aberto | pt_BR |
dc.source | http://dx.doi.org/10.1089/aid.2006.0281. | pt_BR |
dc.subject | AIDS Serodiagnosis | pt_BR |
dc.subject | Atherosclerosis | pt_BR |
dc.title | Cross-sectional study of endothelial function in HIV-infected patients in Brazil | pt_BR |
dc.title.alternative | AIDS Research and Human Retroviruses | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.identifier.number | v. 24, n. 1 | pt_BR |
dc.embargo.liftdate | 10000-01-01 | - |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina) |
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